acute Effects of Electronic Cigarette Inhalation on the Vasculature and the Conducting airways.

Introduction:
This text summarizes a scientific study that examines the acute effects of inhaling electronic cigarette aerosol (ECa) with and without nicotine on vascular and pulmonary function in healthy volunteers. The study aimed to determine if the observed effects were due to the nicotine content or other factors found in the ECa.

Key Points:

* The study used a randomized, double-blinded, crossover design with 17 healthy occasional smokers.
* Volunteers inhaled 30 puffs of ECa with or without nicotine during a 30-minute period on two separate occasions.
* Vascular measurements including heart rate, blood pressure, and arterial stiffness were taken at baseline and following exposure at 0h, 2h, and 4h.
* Pulmonary measurements including dynamic spirometry, impulse oscillometry, and fractional exhaled nitric oxide (FeNO) were carried out following vascular measurements and at 6h post-exposure.
* ECa with nicotine caused a significant increase in heart rate, blood pressure, and arterial stiffness.
* ECa with nicotine also caused a sudden increase in flow resistance as measured by impulse oscillometry, indicating obstruction of the conducting airways.
* Both aerosols caused an increase in blood pressure.

Main Message:
The study indicates that inhaled ECa with nicotine has an acute impact on vascular and pulmonary function. The findings suggest that chronic usage may lead to long-term adverse health effects. Further investigation is warranted to fully understand the potential risks associated with ECa use. It is important for regulators to consider these findings when developing policies and regulations regarding ECa products.

antoniewicz L, Brynedal a, hedman L, Lundbäck M, Bosson Ja. acute Effects of Electronic Cigarette Inhalation on the Vasculature and the Conducting airways. Cardiovascular toxicology. 2019;19(5):441-450. doi:10.1007/s12012-019-09516-x