Computational analysis of deposition and translocation of inhaled nicotine and acrolein in the human body with e-cigarette puffing topographies

Introduction:
This text discusses a study that aimed to predict the systemic translocation of nicotine and acrolein in the human body after inhalation of electronic cigarette (EC) aerosols using a computational model. The model, which combines Computational Fluid-Particle Dynamics (CFPD) and Physiologically Based Toxicokinetic (PBTK) models, was experimentally validated and used to analyze the effects of puff topography on the deposition and translocation of nicotine and acrolein in the respiratory system and systemic region.

Key Points:

* A CFPD-PBTK model was developed and validated to predict the systemic translocation of nicotine and acrolein in the human body after inhalation of EC aerosols.
* The model was used to analyze the effects of puff topography on the deposition and translocation of nicotine and acrolein in the respiratory system and systemic region.
* The study found that puff volume and holding time can contribute to the variations of nicotine and acrolein plasma concentration due to enhanced aerosol deposition in the lung.
* The change in holding time resulted in significant differences in chemical translocation, which was neglected in a large group of experimental studies.
* The model's capability of simulating multiple puffs of EC aerosols provides a valuable computational simulation tool for assessing the chronic health effects of inhaled EC toxicants.
* The study highlights the importance of considering puff topography and holding time in the assessment of EC aerosol health risks.
* The study also underscores the need for further research on the potential health impact of the newly discovered chemical compounds in EC aerosols.

Main Message:
The study emphasizes the importance of using computational models to understand the health risks associated with EC aerosol inhalation. By analyzing the effects of puff topography on the deposition and translocation of nicotine and acrolein in the respiratory system and systemic region, the study demonstrates the potential of CFPD-PBTK models in predicting the health risks associated with EC aerosol inhalation. The study also highlights the need for further research on the potential health impact of the newly discovered chemical compounds in EC aerosols and the importance of considering puff topography and holding time in the assessment of EC aerosol health risks. Overall, the study underscores the need for continued research and regulation of EC aerosols to protect public health.

Haghnegahdar, Ahmadreza, Yu Feng, Xiaole Chen, and Jiang Lin. “Computational Analysis of Deposition and Translocation of Inhaled Nicotine and Acrolein in the Human Body with E-Cigarette Puffing Topographies.” Aerosol Science and Technology 52, no. 5 (May 4, 2018): 483–93. https://doi.org/10.1080/02786826.2018.1447644.