E-cigarette aerosols containing nicotine modulate nicotinic acetylcholine receptors and astroglial glutamate transporters in mesocorticolimbic brain regions of chronically exposed mice.

Chronic inhalation of nicotine within e-cigarette aerosols significantly alters the expression of pre-synaptic nicotinic acetylcholine receptors (naChRs) and astroglial glutamate transporters in specific mesocorticolimbic brain regions. These alterations may mediate the initiation and development of nicotine dependence.

alasmari F, Crotty alexander LE, hammad aM, et al. E-cigarette aerosols containing nicotine modulate nicotinic acetylcholine receptors and astroglial glutamate transporters in mesocorticolimbic brain regions of chronically exposed mice. Chemico-biological interactions. 2021;333:109308. doi:10.1016/j.cbi.2020.109308