Effects of 3-Month Exposure to E-Cigarette aerosols on Glutamatergic Receptors and Transporters in Mesolimbic Brain Regions of Female C57BL/6 Mice.

Three months' exposure to mint- or mango-flavored JUUL (containing 5% nicotine, 59 mg/mL) induced upregulation of metabotropic glutamate receptor 1 (mGluR1) and postsynaptic density protein 95 (phosphorylated and total PSD95) expression, and downregulation of mGluR5 and glutamate transporter 1 (GLT-1) in the Nac-shell. In addition, three months' exposure to JUUL was associated with upregulation of mGluR5 and GLT-1 expression in the hIP. These findings demonstrated that three-month exposure to e-cig vapor containing high nicotine concentrations induced differential effects on the glutamatergic system in the Nac and hIP, suggesting dysregulation of glutamatergic system activity in mesolimbic brain regions.

alhaddad h, Wong W, Sari aT, Crotty alexander LE, Sari Y. Effects of 3-Month Exposure to E-Cigarette aerosols on Glutamatergic Receptors and Transporters in Mesolimbic Brain Regions of Female C57BL/6 Mice. Toxics. 2020;8(4). doi:10.3390/toxics8040095