Electronic cigarette use is negatively associated with body mass index: an observational study of electronic medical records.

Introduction:
This text summarizes a scientific study that examines the potential oral health effects of electronic nicotine delivery systems (ENDS), also known as e-cigarettes. The study uses saliva samples from ENDS users and never tobacco users to assess differential biomarkers of inflammation, toxicity, and disease development.

Key Points:

* The study included 14 current ENDS users and 16 never tobacco users.
* Participants completed questionnaires about their ENDS use and overall health.
* Saliva samples were assessed for differential biomarkers of inflammation, toxicity, and disease development, including evaluation of specific inflammatory cytokines and the global assessment of alterations in metabolites.
* ENDS users were determined to have elevated saliva levels of interleukin-1β and tumor necrosis factor-α, indicating inflammation.
* Metabolite profiling determined 368 metabolites were differentially expressed in the saliva of ENDS users versus never tobacco users.
* Increased levels of prostaglandins and leukotrienes indicated that ENDS users exhibited increased arachidonic acid metabolism compared to never tobacco users.
* Other differentially expressed metabolites included gangliosides, ceramides, angiotensin, and others, which are involved in immune signaling.

Main Message:
The study found that current ENDS users have differential saliva component profiles, including elevated inflammatory markers and altered metabolites, which may contribute to periodontal disease development. These findings suggest specific pathways of oral disease induced by ENDS use and could be utilized as potential future biomarkers. as an expert in regulatory matters, it is essential to consider the potential health risks associated with ENDS use, and this study provides valuable information for regulatory decision-making.

alqahtani MM, alanazi aMM, almutairi aS, Pavela G. Electronic cigarette use is negatively associated with body mass index: an observational study of electronic medical records. Obesity science & practice. 2021;7(2):226-231. doi:10.1002/osp4.468