Summary
Introduction:
This text provides an overview of a study that examines the effects of electronic cigarettes (ECs) on human brain beta-2 nicotinic acetylcholine receptors (β2*-naChRs) using PET neuroimaging with (-)-[18F]Flubatine, a novel radiotracer. The study aimed to determine the degree to which ECs deliver nicotine to the human brain and how this compares to tobacco cigarettes.
Key Points:
* The study included four experienced EC users and three cigarette smokers.
* PET imaging and (-)-[18F]Flubatine were used to measure receptor occupancy and arterial blood nicotine levels after EC use or cigarette smoking.
* average β2*-naChR occupancy was higher after 36 mg/ml EC challenge compared with 8 mg/ml EC at trend level.
* Receptor occupancy and arterial blood nicotine levels after cigarette smoking were similar to 36 mg/ml EC use under controlled conditions.
* The study suggests that the ECs studied have abuse liability and may provide an adequate alternative nicotine delivery system for cigarette smokers.
* The study is limited by the small sample size and the use of a single EC device and liquid formulation.
* Further studies are needed to expand understanding of EC abuse liability and how they compare to traditional cigarettes.
Main Message:
The study provides novel insights into the neurologic effects of electronic cigarettes on human brain beta-2 nicotinic acetylcholine receptors. The findings suggest that the ECs studied have abuse liability and may provide an adequate alternative nicotine delivery system for cigarette smokers. however, the study is limited by the small sample size and the use of a single EC device and liquid formulation. Further studies are needed to confirm and expand upon these findings. It is important to continue to evaluate the potential benefits and harms of ECs as the use of these products continues to rise.
Citation
Baldassarri SR, hillmer aT, anderson JM, et al. Use of electronic cigarettes leads to significant beta2-nicotinic acetylcholine receptor occupancy: Evidence from a PET imaging study. Nicotine & Tobacco Research. 2018;20(4):425-433. doi:10.1093/ntr/ntx091
