Summary
Introduction:
This article is a summary of a scientific study that investigates the effects of propylene glycol (PG) and vegetable glycerin (VG), the main constituents of electronic cigarette (e-cigarette) liquid, on gingival epithelial cells. The study aims to evaluate the cytotoxicity and activation of biological mediators in response to exposure to PG/VG mixtures, both with and without nicotine.
Key Points:
* The study found that exposure to PG/VG mixtures reduced cell viability in gingival epithelial cells.
* The amount of PG had a greater biological impact compared to the VG amount.
* Nicotine augmented the effect of PG/VG mixtures on cell viability and biological mediator expression.
* The study measured the expression of interleukin (IL)-6, IL-8, and matrix metalloproteinases (MMPs)-9 and found that they were increased in response to PG/VG exposure.
* MMP-9 was clearly activated in almost all samples.
* The findings suggest that PG/VG are cytotoxic and able to induce a biological response in gingival cells.
* The study concludes that despite being advertised as less harmful than conventional cigarettes, e-cigarette liquid poses certain risks on periodontal cells.
Main Message:
The main message of this study is that e-cigarette liquid, specifically the PG/VG mixtures, are not harmless and can have negative effects on periodontal cells. The study highlights the need for increased awareness about the potential risks of e-cigarette use, particularly in relation to periodontal health. It is important for regulatory bodies to consider these findings when evaluating the safety of e-cigarettes and for healthcare providers to inform their patients about the potential risks of e-cigarette use.
Citation
Beklen a, Uckan D. Electronic cigarette liquid substances propylene glycol and vegetable glycerin induce an inflammatory response in gingival epithelial cells. human & experimental toxicology. 2021;40(1):25-34. doi:10.1177/0960327120943934
