Comparing the Effectiveness, Tolerability, and Acceptability of Heated Tobacco Products and Refillable Electronic Cigarettes for Cigarette Substitution (CEASEFIRE): Randomized Controlled Trial.

Introduction:
This text presents the CONSORT 2010 checklist, a set of guidelines for reporting randomized trials. The checklist aims to improve the transparency and completeness of trial reports, enabling readers to better assess the validity and applicability of the trial results. By following these evidence-based recommendations, researchers can enhance the quality of their trial reporting and facilitate the critical appraisal of their work by regulators, clinicians, and other stakeholders.

Key Points:

* The CONSORT 2010 checklist includes 25 items, covering various aspects of trial design, methods, participant flow, outcomes, and other relevant information.
* The checklist emphasizes the importance of identifying the trial as randomized in the title, providing a structured summary, and disclosing the scientific background and objectives.
* Researchers should clearly describe the trial design, eligibility criteria, interventions, and outcome measures, including any changes made during the trial.
* The checklist encourages the use of diagrams to illustrate participant flow and reporting details on recruitment, baseline data, and numbers analyzed.
* Researchers must provide estimates of effect size and precision, along with information on harms, trial limitations, and generalizability.
* The text recommends registering the trial, disclosing the funding sources, and providing access to the full trial protocol.
* The CONSORT 2010 checklist should be used in conjunction with relevant extensions, such as those for cluster randomized trials, non-inferiority trials, and herbal interventions.

Main Message:
The main message of this text is the importance of adhering to the CONSORT 2010 checklist when reporting randomized trials. By following these guidelines, researchers can ensure that their trial reports are comprehensive, transparent, and accessible to a wide range of stakeholders. This, in turn, promotes better-informed decision-making, enhances the credibility of research findings, and facilitates evidence-based practice and policy development. Therefore, it is crucial for researchers to understand and apply the CONSORT 2010 checklist to maximize the impact and value of their trial results.

Caponnetto P, Campagna D, Maglia M, et al. Comparing the Effectiveness, Tolerability, and Acceptability of Heated Tobacco Products and Refillable Electronic Cigarettes for Cigarette Substitution (CEASEFIRE): Randomized Controlled Trial. JMIR public health and surveillance. 2023;9:1. doi:10.2196/42628