Summary
Introduction:
This text discusses the study on the effects of electronic cigarette (e-cigarette) aerosol inhalation on vascular function in young, healthy nonsmokers. The study used quantitative MRI metrics to evaluate peripheral and cerebrovascular reactivity, as well as aortic pulse wave velocity before and after e-cigarette aerosol inhalation. The text also covers the test-retest repeatability of the MRI protocol and the statistical analysis used in the study.
Key Points:
• The study enrolled 31 healthy never-smokers aged 18-35 years.
• Participants underwent MRI scans before and after inhaling nicotine-free e-cigarette aerosol.
• The MRI protocol assessed peripheral and cerebrovascular reactivity, as well as aortic pulse wave velocity.
• Test-retest repeatability was assessed for each element of the protocol.
• after e-cigarette aerosol inhalation, participants showed transient impairment of vascular reactivity and endothelial function.
• Femoral artery flow-mediated dilation and reactive hyperemia acceleration were reduced.
• hemoglobin saturation was reduced in the superficial femoral vein, indicating impaired microvascular function.
• aortic pulse wave velocity was increased, suggesting acute aortic stiffening.
Main Message:
The study found that inhaling nicotine-free electronic cigarette aerosol transiently impacts endothelial function in healthy nonsmokers. The findings suggest that further studies are needed to address the potentially adverse long-term effects on vascular health. as an expert in regulatory matters, it is crucial to consider these results when evaluating the safety and risks associated with e-cigarette use. The study highlights the need for more research to fully understand the effects of e-cigarette aerosol on vascular function and health.
Citation
Caporale a, Langham MC, Guo W, Johncola a, Chatterjee S, Wehrli FW. acute Effects of Electronic Cigarette aerosol Inhalation on Vascular Function Detected at quantitative MRI. Radiology. 2019;293(1):97-106. doi:10.1148/radiol.2019190562
