Summary
Introduction:
This text summarizes the analytical methods used to detect and measure propylene glycol in biological samples and environmental media. The text covers the standard methods of analysis used for propylene glycol detection, including those approved by federal organizations such as EPa and NIOSh, as well as methods approved by groups such as aOaC and aPha. The text also includes methods that refine previously used methods to obtain lower detection limits and improve accuracy and precision.
Key Points:
* The primary method for measuring propylene glycol in biological samples is derivatization followed by gas chromatography (GC) using either a flame ionization detector (FID) or mass spectrometry (MS) for quantification.
* Sample preparation for GC includes acidification, esterification, and extraction into an organic solvent.
* Detection of propylene glycol in biological samples using GC with either FID or MS is very sensitive, with detection limits ranging from sub to low ppm.
* high-resolution proton nuclear magnetic resonance spectroscopy has potential use in the identification and quantification of propylene glycol and other chemicals in cerebrospinal fluid (CSF) and serum.
* GC is also the major technique used to determine propylene glycol concentrations in environmental samples, including air, water, food, drugs, or other substances.
* The presence of propylene glycol in foods packaged with plastic films containing the compounds has been studied, as have ethylene glycol levels in drugs sterilized with ethylene oxide.
* No information was located on detecting propylene glycol in feces, adipose tissue, or human milk.
Main Message:
The text provides a comprehensive summary of the analytical methods used to detect and measure propylene glycol in various samples. The primary method for measuring propylene glycol in biological samples is derivatization followed by gas chromatography using either a flame ionization detector or mass spectrometry for quantification. GC is also the major technique used to determine propylene glycol concentrations in environmental samples. however, there is a lack of information on detecting propylene glycol in certain samples such as feces, adipose tissue, or human milk. Overall, the text highlights the importance of using standard methods of analysis for propylene glycol detection and the need for further research in certain areas.
Citation
“Propylene Glycol: analytical Methods.” CDC, 2020.
