In vivo assessment of the toxicity of electronic cigarettes to zebrafish (Danio rerio) embryos, following gestational exposure, in terms of mortality, developmental toxicity, and hair cell damage: Toxicity of E-cigs to zebrafish embryos.
Introduction:
This article presents a study on the toxicity of electronic cigarette (E-cig) liquids to zebrafish (Danio rerio) embryos following gestational exposure. The study evaluates hair cell damage and developmental toxicities caused by E-cig liquids.
Key Points:
* Zebrafish embryos were exposed to E-cig liquids at different concentrations (0.1%, 0.2%, and 0.4%).
* Embryonic developmental toxicity and hair cell damage were evaluated at 6 and 7 days post-fertilization, respectively.
* The average number of hair cells in the anterior lateral line (aLL) and posterior lateral line (PLL) following E-cig exposure was compared to that of the control.
* Morphological abnormalities and heart rate were evaluated.
* E-cig liquids significantly damaged the hair cells in the aLL, compared to the control.
* at high concentrations, E-cig liquids significantly damaged the hair cells in the PLL.
* No morphological abnormalities in body shape, somites, notochord, tail, and pectoral fin were observed; however, abnormalities were observed in the dorsal fin and heart rate at high concentrations.
Main Message:
The study suggests that gestational exposure to E-cigs significantly damages hair cells in a concentration-dependent manner and induces developmental toxicities to the dorsal fin and heart rate at high concentrations. These findings highlight the potential risks associated with the use of E-cigs and the need for further research to better understand their toxicity. It is important for regulatory agencies to consider these risks when evaluating the safety of E-cig products.
Citation
Chang YS, Park SM, Rah YC, et al. In vivo assessment of the toxicity of electronic cigarettes to zebrafish (Danio rerio) embryos, following gestational exposure, in terms of mortality, developmental toxicity, and hair cell damage: Toxicity of E-cigs to zebrafish embryos. human & experimental toxicology. 2021;40(1):148-157. doi:10.1177/0960327120947785
Chang YS, Park SM, Rah YC, et al. In vivo assessment of the toxicity of electronic cigarettes to zebrafish (Danio rerio) embryos, following gestational exposure, in terms of mortality, developmental toxicity, and hair cell damage: Toxicity of E-cigs to zebrafish embryos. human & experimental toxicology. 2021;40(1):148-157. doi:10.1177/0960327120947785
