The Effect of Flavored E-cigarettes on Murine allergic airways Disease.

Introduction:
This text is a scientific report on a study that examines the effects of flavored e-cigarettes with and without nicotine on allergic airways disease in a mouse model. The study aims to determine the potential toxicity of these products for patients with asthma.

Key Points:

* The study used a mouse model of allergic airways disease and exposed the mice to various flavored e-cigarettes with and without nicotine.
* The study found that flavored e-cigarettes without nicotine can alter allergic airways disease, but the effect is dependent on the specific flavor.
* Nicotine universally dampened airway inflammation independent of flavor, with no effect on ahR or airway remodeling.
* The study also found that exposure to Banana Pudding without nicotine increased soluble lung collagen content in mice with allergic airways disease.
* The study suggests that airway remodeling may be linked to specific flavor additives rather than nicotine.
* The study also highlights the potential for flavored e-cigarettes to contribute to lung fibrosis and immune dysfunction.
* The findings from the study may suggest that e-cigarettes are less likely to worsen asthma pathophysiology than tobacco cigarette smoking.

Main Message:
The study highlights the potential for flavored e-cigarettes, in the absence of nicotine, to negatively contribute to asthma outcomes. The findings suggest that further investigation into the individual chemical constituents of e-cigarettes driving these toxic effects is necessary for the regulation of e-cigarettes. Overall, the study emphasizes the need for caution in promoting the use of flavored e-cigarettes to patients with asthma.

Chapman DG, Casey DT, ather JL, et al. The Effect of Flavored E-cigarettes on Murine allergic airways Disease. Scientific reports. 2019;9(1):13671. doi:10.1038/s41598-019-50223-y