Short halt in vaping modifies cardiorespiratory parameters and urine metabolome: a randomized trial.

Introduction:
This text provides an overview of a randomized trial investigating the impact of a short halt in vaping on cardio-respiratory parameters and the urine metabolome. The study's methodology, participant details, and key findings are discussed.

Key Points:

* The study involved 26 participants, who were divided into three sessions: nicotine, nicotine-free, and stop.
* The trial design included various measurements such as pulse oximetry, transcutaneous oxygen/carbon dioxide tensions, end-tidal carbon dioxide, respiratory rhythm, skin microcirculatory blood flow, continuous vascular conductance, lung function tests, and diffusing capacity.
* Biomarkers such as club cell protein-16, surfactant protein-D, and propylene glycol were also analyzed.
* The trial adhered to the Declaration of helsinki and was approved by the local Ethics Committee.
* Informed consent was obtained from all study participants.
* The trial was registered at ClinicalTrials.gov.
* The study found that a short halt in vaping modified cardio-respiratory parameters and the urine metabolome.

Main Message:
The study provides valuable insights into the impact of vaping cessation on cardio-respiratory parameters and the urine metabolome. The trial's rigorous design and adherence to ethical guidelines strengthen the findings, which could have important implications for public health and tobacco control policies. The results suggest that even a short halt in vaping can have significant benefits on cardio-respiratory health, highlighting the importance of promoting cessation among vapers.

Chaumont M, Tagliatti V, Channan EM, et al. Short halt in vaping modifies cardiorespiratory parameters and urine metabolome: a randomized trial. american journal of physiology Lung cellular and molecular physiology. 2020;318(2):L331-L344. doi:10.1152/ajplung.00268.2019