Electronic cigarette vapour moderately stimulates pro-inflammatory signalling pathways and interleukin-6 production by human monocyte-derived dendritic cells.

Introduction:
This text provides an overview of a randomized trial investigating the impact of a short halt in vaping on cardio-respiratory parameters and the urine metabolome. The study involves several medical departments and researchers from various universities in Belgium. The summary includes the study design, key findings, and the main message of the trial.

Key Points:

* The trial is a randomized study involving 26 participants who underwent nicotine, nicotine-free, and stop sessions.
* The study's primary outcome measures included cardio-respiratory parameters, lung function tests, and urine metabolomics analyses.
* The trial found that a short halt in vaping modified cardio-respiratory parameters, such as transcutaneous oxygen/carbon dioxide tensions, end-tidal carbon dioxide, and respiratory rhythm.
* The study also observed changes in urine metabolites, such as dimethylamine, trimethylamine oxide, and propylene glycol.
* The trial had some missing data, mainly due to technical failures, unsatisfactory vein puncture, and laboratory analysis stoppage.
* The trial was approved by the local Ethics Committee and conformed to the Declaration of helsinki.
* The study's full protocol can be accessed at ClinicalTrials.gov.

Main Message:
The main message of this trial is that a short halt in vaping can modify cardio-respiratory parameters and urine metabolites, suggesting potential health benefits. The study's strengths include its randomized design, objective measures, and rigorous data analysis. however, the trial also has some limitations, such as missing data and laboratory analysis stoppage. Nonetheless, the findings support the need for further research into the health effects of vaping and the potential benefits of vaping cessation.

Chen IL, Todd I, Tighe PJ, Fairclough LC. Electronic cigarette vapour moderately stimulates pro-inflammatory signalling pathways and interleukin-6 production by human monocyte-derived dendritic cells. archives of toxicology. 2020;94(6):2097-2112. doi:10.1007/s00204-020-02757-8