Summary
Introduction:
This text presents the results of a study that analyzed the levels of a specific DNa adduct, γ-Oh-acr-dGuo, in oral cells from e-cigarette users and non-users. The study also examined the relationship between age, gender, and the levels of this DNa adduct. additionally, the text discusses the potential implications of these findings for the health risks associated with e-cigarette use.
Key points:
* The study analyzed the levels of γ-Oh-acr-dGuo in oral cells from 20 e-cigarette users and 20 non-users.
* The levels of this DNa adduct were significantly higher in e-cigarette users compared to non-users (average median value of 178.8 fmol/µmol dGuo vs. 21.0 fmol/µmol dGuo, respectively).
* The study also found that the levels of γ-Oh-acr-dGuo in oral cells were correlated with age in both e-cigarette users and non-users.
* Gender had no significant effect on the levels of this DNa adduct.
* The study estimated that the range of contributions of bacterial DNa to the analyzed DNa was 0.002-2.7% for e-cigarette users and 0.006-4.4% for non-users.
* The study notes that two cases of oral cancer in chronic exclusive e-cigarette users have been reported.
* The text discusses the potential implications of these findings for the health risks associated with e-cigarette use, but emphasizes that cigarette smoking is far worse due to higher exposure to acrolein and multiple other carcinogens.
Main message:
The study provides evidence that e-cigarette use is associated with higher levels of a specific DNa adduct, γ-Oh-acr-dGuo, in oral cells. While the study emphasizes that cigarette smoking is far more harmful than e-cigarette use, the findings suggest that e-cigarette use may also pose health risks. Further research is needed to understand the potential toxic and carcinogenic effects of e-cigarette use.
Citation
Cheng G, Guo J, Carmella SG, et al. Increased acrolein-DNa adducts in buccal brushings of e-cigarette users. Carcinogenesis. 2022;43(5):437-444. doi:10.1093/carcin/bgac026
