Summary
Introduction:
This summary will provide an overview of a research article examining the impact of e-cigarette aerosol condensate (EaC) on endothelial cell health and the cardiovascular system. The study investigates the effects of EaC, both with and without nicotine, on human coronary artery endothelial cells (hCaEC) and in vivo on the cardiovascular system using a mouse model of 'e-vaping.'
Key Points:
* The study found that EaC decreased cell viability in hCaEC and increased reactive oxygen species (ROS) levels in both direct and indirect exposures.
* In conditioned lung cell media, EaC increased ICaM-1 protein expression, an early event in atherogenesis.
* Ex vivo results showed an increase in the mRNa levels of anti-angiogenic marker, FKBPL, and endothelial cell adhesion molecule involved in barrier function, ICaM-1, in murine hearts following exposure to electronic cigarette aerosol treatment containing a higher amount of nicotine.
* Immunohistochemistry revealed an upregulation of FKBPL and ICaM-1 protein expression levels.
* The study suggests that despite e-cigs being widely used for tobacco smoking cessation, these can negatively impact endothelial cell health with a potential to lead to the development of cardiovascular disease.
Main Message:
The study emphasizes the potential risks associated with e-cigarette use, particularly in relation to endothelial cell health and the development of cardiovascular disease. The findings suggest that both direct and indirect exposure to EaC, and the presence of nicotine, can negatively impact endothelial cells and lead to the activation of early events in atherogenesis. as such, it is crucial to consider these risks when promoting e-cigarettes as a safer alternative to traditional cigarettes.
Citation
Chhor M, Tulpar E, Nguyen T, et al. E-Cigarette aerosol Condensate Leads to Impaired Coronary Endothelial Cell health and Restricted angiogenesis. International journal of molecular sciences. 2023;24(7). doi:10.3390/ijms24076378
