Vascular effects of a single bout of electronic cigarette use.

Introduction:
This text provides an in-depth analysis of electronic cigarettes (EC) and their potential effects on the cardiovascular system. The reader will learn about the background of EC, the impact of EC on endothelial function and arterial stiffness, and the role of nicotine, menthol, propylene glycol, and glycerol in EC. The text also includes a summary of a study that examines the acute changes in arterial stiffness and endothelial function after smoking EC.

Key Points:

* Electronic cigarettes have gained popularity in recent years, especially among young adults.
* While EC are marketed as a safer alternative to traditional cigarettes, little is known about their effects on the cardiovascular system.
* EC have been shown to contain harmful substances, including carbonyls, aldehydes, and trace metals.
* The study found no significant changes in subclinical vascular functions with ECs containing 5.4% and 0% nicotine.
* The lack of significance may be due to an inappropriate dose of nicotine or the use of a menthol inhaler as a sham control.
* The study used CaVI to measure arterial stiffness, which is a reliable and non-technical method.
* The study did not observe significant differences in FMD change between the 5.4% and 0% conditions.
* The study had a small sample size and limitations, such as non-consecutive trials and a limited vaping location.

Main Message:

The text highlights the need for further research on the effects of EC on the cardiovascular system. While the study found no significant changes in subclinical vascular functions with EC containing 5.4% and 0% nicotine, the limitations of the study suggest that more extensive research is necessary. The study's use of CaVI to measure arterial stiffness is a reliable method, and the lack of significant differences in FMD change between the 5.4% and 0% conditions is noteworthy. however, the small sample size and limitations of the study make it difficult to draw definitive conclusions. Therefore, it is essential to continue researching the effects of EC on the cardiovascular system to ensure the safety and well-being of users.

Cossio R, Cerra Za, Tanaka h. Vascular effects of a single bout of electronic cigarette use. Clinical and experimental pharmacology & physiology. 2020;47(1):3-6. doi:10.1111/1440-1681.13180