an approach to allergy risk assessments for e-liquid ingredients

Introduction:
This manuscript presents an approach for assessing and managing the risk of allergens in e-liquid ingredients. The reader will learn about the importance of identifying and assessing contact and respiratory allergens in e-liquids, as well as strategies for risk management. The manuscript also includes a case study on the respiratory sensitization risk assessment of cocoa shell extract.

Key Points:

* The manuscript proposes a "how to" guide for a vaping contact allergy quantitative risk assessment.
* The authors recommend avoiding the use of respiratory allergens in e-liquids.
* The case study on cocoa shell extract demonstrates the process of assessing the respiratory sensitization risk of an ingredient.
* The study found that cocoa shell extract has the potential to induce type I allergy in humans and recommended against using it in inhalation products.
* The authors suggest identifying food allergens on product labels for consumers with known or self-suspected food allergies.
* The European food regulations are recommended as a source of information on compounds that have been established as potential food allergens.
* The study recommends against using any compounds that can induce IgE-mediated allergy in inhalation products.
* For listed compounds with no evidence of IgE-mediated mechanisms, the study suggests informing consumers of their presence in a list of ingredients on the packaging or by adding a specific warning.

Main Message:
The main message of this manuscript is the importance of identifying and assessing allergens in e-liquid ingredients and implementing strategies for risk management. The authors emphasize the need to avoid respiratory allergens and provide a case study on the respiratory sensitization risk assessment of cocoa shell extract. The study highlights the potential risks associated with using certain ingredients and the importance of informing consumers about the presence of potential allergens. Overall, the manuscript provides valuable information for regulators, manufacturers, and consumers regarding allergy risk assessments for e-liquid ingredients.

Costigan, Sandra, and Juan Lopez-Belmonte. “an approach to allergy Risk assessments for E-Liquid Ingredients.” Regulatory Toxicology and Pharmacology 87 (July 2017): 1–8. https://doi.org/10.1016/j.yrtph.2017.04.003.