a novel application of the Margin of Exposure approach: Segregation of tobacco smoke toxicants

Introduction:
This article presents a novel application of the Margin of Exposure (MOE) approach to the segregation of tobacco smoke toxicants for risk assessment and management purposes. The MOE approach has been used to compare and rank substances, set targets for risk reduction strategies, and evaluate a range of data sets, including genotoxic, carcinogenic, and non-cancer.

Key Points:

* The MOE approach has been used to calculate the relationship between the dose of or exposure to a chemical and the estimated human intake.
* The MOE approach has been applied to tobacco smoke toxicants, and a range of MOEs have been calculated for each toxicant using data from multiple studies.
* The MOE values have been used to segregate individual tobacco smoke toxicants into either a high or low priority for risk reduction research.
* The MOE approach has been found to be useful in identifying toxicants and areas where additional data needs to be generated from inhalation studies.
* The MOE model lacks complexity and additional refinements may be necessary to customize it for the special situation of human exposure to tobacco smoke.
* The MOE approach has been used to rank toxicants according to MOEs, but further research is needed to validate this ranking system.
* a precautionary risk assessment approach has been suggested for the prioritization of toxicants.

Main Message:
The MOE approach has been found to be a useful tool for the segregation and prioritization of tobacco smoke toxicants for risk reduction research. however, further research is needed to validate the ranking system and to refine the MOE model for the special situation of human exposure to tobacco smoke. a precautionary risk assessment approach has been suggested for the prioritization of toxicants. Overall, the MOE approach provides a valuable framework for the assessment and management of tobacco smoke toxicants.

Cunningham, F.h., S. Fiebelkorn, M. Johnson, and C. Meredith. “a Novel application of the Margin of Exposure approach: Segregation of Tobacco Smoke Toxicants.” Food and Chemical Toxicology 49, no. 11 (November 2011): 2921–33. https://doi.org/10.1016/j.fct.2011.07.019.