harmful chemicals emitted from electronic cigarettes and potential deleterious effects in the oral cavity.

Introduction:
This review paper discusses the potential oral health effects of using electronic nicotine delivery systems (ENDS), such as electronic cigarettes (e-cigs), and their impact on oral health. The paper highlights the harmful chemicals found in e-cig vapors, including reactive aldehydes, carbonyls, flavoring chemicals, and reactive oxygen species (ROS), and their potential to alter or damage epithelial cells in the oral cavity. The paper also discusses the effects of e-cig aerosols on immune cells and the potential for increased periodontal disease risk.

Key Points:

* E-cigs contain varying levels of nicotine and other chemicals known to increase the risk of cancer.
* Toxic compounds, such as heavy metals, carbonyls, flavoring chemicals, and ROS, have been detected in e-cig aerosols in concentrations that can adversely affect oral health.
* E-cigs are also known to emit amounts of carbonyls that depend on e-cig vaping conditions, such as vaping topography, power output, device construction, coil material, and e-liquid components.
* Exposure to these metals is of concern as it can cause chronic periodontitis, oral cancer, inflammation, and neurodegeneration.
* E-cig aerosols significantly decrease glutathione levels in oral keratinocytes leading to increased cytotoxicity.
* E-cig aerosols induce ROS, DNa damage and toxicity for vascular endothelial cells.
* E-cig use has been associated with increased carbonyl retentions in e-cig users during vaping.
* The high oronasal retention of formaldehydes and acetaldehydes could worsen oral health, but there have been no reports yet on how inhaled e-cig formaldehydes and other toxic aldehydes are associated with oral diseases.

Main Message:
This review paper highlights the potential oral health risks associated with using e-cigs, including the presence of harmful chemicals in e-cig vapors and their potential to alter or damage epithelial cells in the oral cavity. The paper also discusses the effects of e-cig aerosols on immune cells and the potential for increased periodontal disease risk. While the long-term health effects of e-cig use are still not fully understood, this paper emphasizes the need for further research to better understand the potential oral health risks associated with e-cig use. healthcare professionals should be aware of these potential risks and inform their patients accordingly.

Ebersole J, Samburova V, Son Y, et al. harmful chemicals emitted from electronic cigarettes and potential deleterious effects in the oral cavity. Tobacco induced diseases. 2020;18:41. doi:10.18332/tid/116988