Introduction:
This text discusses a study on the analysis of nicotine in electronic cigarette (ECIG) liquids and aerosols. The study aims to determine the partitioning of nicotine between its free-base (Nie) and protonated (Nich+) forms using a liquid-liquid extraction (LLE) method. The study also examines the correlation between nicotine partitioning and ph in ECIG liquids and aerosols.
Key Points:
* The LLE method was validated and used to analyze nicotine in ECIG liquids and aerosols.
* Most nicotine in ECIG liquids and aerosols was found to be in the Nie form.
* The aerosols exhibited a higher Nie fraction than the parent liquids.
* The apparent ph of ECIG liquids was found to correlate with nicotine partitioning.
* The labeled nicotine concentration in commercial products was often inconsistent with the measured nicotine content.
* The study highlights the importance of accurate nicotine quantification and its partitioning in ECIG liquids and aerosols.
* The findings suggest that ECIG liquids of the same total nicotine concentration may result in different nicotine uptake efficiencies when vaped.
* The study emphasizes the need for standardization of nicotine labeling and product conformance standards.
Main Message:
The study highlights the importance of accurate nicotine quantification and its partitioning in ECIG liquids and aerosols. The findings suggest that ECIG liquids of the same total nicotine concentration may result in different nicotine uptake efficiencies when vaped. Therefore, the study emphasizes the need for standardization of nicotine labeling and product conformance standards to ensure the safe and effective use of ECIGs.
Citation
El-hellani, ahmad, Rachel El-hage, Rima Baalbaki, Rola Salman, Soha Talih, alan Shihadeh, and Najat a. Saliba. “Free-Base and Protonated Nicotine in Electronic Cigarette Liquids and aerosols.” Chemical Research in Toxicology 28, no. 8 (august 17, 2015): 1532–37. https://doi.org/10.1021/acs.chemrestox.5b00107.
El-hellani, ahmad, Rachel El-hage, Rima Baalbaki, Rola Salman, Soha Talih, alan Shihadeh, and Najat a. Saliba. “Free-Base and Protonated Nicotine in Electronic Cigarette Liquids and aerosols.” Chemical Research in Toxicology 28, no. 8 (august 17, 2015): 1532–37. https://doi.org/10.1021/acs.chemrestox.5b00107.
