Summary
The document presents a study on the effects of electronic cigarette vapor (ECV) and tobacco cigarette smoke (TCS) on cardiovascular function, specifically focusing on vascular relaxation and the role of nicotine (NIC) in long-term exposure. The study was approved by the Institutional Laboratory animal Care and Use Committee of The Ohio State University and adhered to the National Institutes of health Guidelines for the Care and Use of Laboratory animals.
The researchers monitored blood pressure and vascular response changes in mice exposed to ECV and TCS for 60 weeks. They observed the onset of mild hypertension in the TCS and ECV groups with nicotine at 8 weeks, while no significant blood pressure elevation was found in the ECV exposure groups with low or no nicotine. By 16 weeks, blood pressure elevation correlated with the nicotine exposure level.
The study also found that TCS exposure led to relative ventricular dilatation and decreased ejection fraction and fractional shortening at 60 weeks, while ECV exposure did not result in these changes. heart rate and cardiac output did not show significant changes in any of the groups throughout the exposure times. Systemic vascular resistance was calculated and found to increase as a function of mean blood pressure and cardiac output in all exposure groups.
In summary, this study provides insight into the long-term cardiovascular effects of ECV compared to TCS, highlighting the role of nicotine in this process. It reveals that TCS exposure can lead to ventricular dilatation and decreased cardiovascular function, while ECV exposure does not result in these changes over the same period.
Citation
El-Mahdy Ma, Mahgoup EM, Ewees MG, Eid MS, abdelghany TM, Zweier JL. Long-term electronic cigarette exposure induces cardiovascular dysfunction similar to tobacco cigarettes: role of nicotine and exposure duration. american journal of physiology heart and circulatory physiology. 2021;320(5):h2112-h2129. doi:10.1152/ajpheart.00997.2020
