Flavorant-Solvent Reaction Products and Menthol in JUUL E-Cigarettes and aerosol.

Introduction:
This text is a summary of a scientific study examining the composition of aerosols produced by JUUL electronic cigarettes, specifically focusing on the presence and carryover of certain flavorant-solvent reaction products, menthol, and nicotine benzoate salt. The study aims to understand potential human exposures to these compounds when using JUUL e-cigarettes.

Key Points:

* The study utilized a custom-built vaping machine to capture aerosol and analyzed the samples using gas chromatography mass spectroscopy.
* Vanillin PG acetal and vanillin VG acetals were detected in JUUL's "Crème Brulée" e-liquid and carried over to aerosol at 68 ± 4% and 59 ± 20%, respectively.
* Menthol was found in four of the eight tested flavors, with aerosol concentrations comparable to mentholated cigarettes.
* Nicotine and benzoic acid carryover were high, but only benzoic acid showed statistical significance between e-liquid and aerosol concentrations.
* absolute nicotine aerosol content was comparable to previous reports analyzing JUUL or combustible cigarettes.
* This study is the first to report the presence of flavor aldehyde VG acetals in e-liquids and aerosols, and identifies potential toxicologic properties of these new compounds.
* The formation of new compounds and the exposure to menthol and flavorant-solvent reaction products in e-cigarettes should be addressed in future regulatory policies.

Main Message:
The study highlights the importance of understanding the composition of aerosols produced by e-cigarettes, particularly JUUL products. The presence and carryover of certain flavorant-solvent reaction products, menthol, and nicotine benzoate salt in JUUL aerosols may have potential health implications for users. These findings emphasize the need for further research and regulatory policies to ensure the safety and public health impact of e-cigarettes.

Erythropel hC, Davis LM, de Winter TM, et al. Flavorant-Solvent Reaction Products and Menthol in JUUL E-Cigarettes and aerosol. american journal of preventive medicine. 2019;57(3):425-427. doi:10.1016/j.amepre.2019.04.004