Association of Electronic Nicotine Delivery System Use With Cigarette Smoking Relapse Among Former Smokers in the United States.

Introduction:
This text provides an analysis of a study examining the association between electronic nicotine delivery system (ENDS) use and cigarette smoking relapse among former cigarette smokers. The study uses data from the Population Assessment of Tobacco and Health Study and employs a longitudinal cohort design to assess the risk of cigarette smoking relapse among recent and long-term former smokers who use ENDS.

Key Points:

* The study found that use of ENDS and other tobacco products was associated with an increased risk of cigarette smoking relapse among former cigarette smokers who did not use any tobacco product at wave 1.
* The association between ENDS use and cigarette smoking relapse was significant for both recent and long-term former smokers.
* Use of other tobacco products was also associated with an increased risk of cigarette smoking relapse.
* The study controlled for various factors such as internalizing, externalizing, and substance use problems, past cigarette use behavior, and sociodemographic variables.
* The sample was representative of the US civilian, noninstitutionalized population, and the study used full-sample and replicate weights to adjust for the complex sample design and nonresponse.
* The study used Cox proportional hazards models to assess the associations between ENDS use and cigarette smoking relapse.
* The study examined recent and long-term former cigarette smokers both together and separately to assess whether ENDS have a differential effect on those with early or established abstinence.

Main Message:
The main message of the text is that use of ENDS and other tobacco products is associated with an increased risk of cigarette smoking relapse among former cigarette smokers who have successfully quit all nicotine products. The study suggests that for clinicians treating former smokers, the implications are that use of ENDS products should be discouraged, just as use of all other tobacco products is discouraged. The study contributes to the evidence base to inform the Food and Drug Administration’s regulatory mission and to inform clinicians, public health workers, or others treating former smokers.

Everard CD, Silveira ML, Kimmel HL, Marshall D, Blanco C, Compton WM. Association of Electronic Nicotine Delivery System Use With Cigarette Smoking Relapse Among Former Smokers in the United States. JAMA network open. 2020;3(6):1. doi:10.1001/jamanetworkopen.2020.4813