Toxicity classification of e-cigarette flavouring compounds based on European Union regulation: analysis of findings from a recent study.

Introduction:
This text discusses a study that analyzes the toxicity classification of e-cigarette flavoring compounds based on European Union regulation. The study calculates the toxicity classification for different health hazards for all the flavouring chemicals at the maximum concentrations reported in a recent study.

Key Points:

* The study uses the European Union Classification Labelling and Packaging regulation to estimate the toxicity classification of e-cigarette flavoring compounds.
* The analysis is based on the maximum concentrations reported in a recent study.
* The study calculates the toxicity classification for different health hazards for all the flavouring chemicals.
* The study finds that one chemical (methyl cyclopentenolone) is found at a maximum concentration 150.7% higher than that needed to be classified as toxic.
* The rest of the chemicals have maximum reported concentrations that are 71.6% to > 99.9% lower than toxicity concentrations.
* a liquid containing all flavouring compounds at the maximum concentrations would be classified as toxic for one category only due to the presence of methyl cyclopentenolone.
* a liquid without methyl cyclopentenolone would have 66.7% to > 99.9% lower concentrations of flavourings than those needed to be classified as toxic.

Main Message:
The study finds that the vast majority of flavouring compounds in e-cigarette liquids are present at levels far lower than needed to classify them as toxic. however, since exceptions exist, the study concludes that regulatory monitoring of liquid composition is warranted.

Farsalinos K, Lagoumintzis G. Toxicity classification of e-cigarette flavouring compounds based on European Union regulation: analysis of findings from a recent study. harm Reduction Journal. 2019;16:8. doi:10.1186/s12954-019-0318-2