alterations in Vascular Function associated With the Use of Combustible and Electronic Cigarettes.

Introduction:
This text is a scientific article published in the Journal of the american heart association that examines the association between electronic cigarette (e-cigarette) use and measures of vascular function and tonometry. The study aims to compare vascular function between combustible cigarette users and users of e-cigarettes, alone or with contemporaneous use of combustible cigarettes. The article also discusses the implications of the findings for the potential use of e-cigarettes as a harm reduction tool for combustible cigarette smokers.

Key Points:

* The study included 457 participants who were classified as nonsmokers, combustible cigarette smokers, e-cigarette users, or dual users.
* The study measured vascular function using noninvasive methods, including pulse wave velocity, augmentation index, central blood pressure, and heart rate.
* In multivariable models adjusted for age, sex, race, and study site, combustible cigarette smokers had higher augmentation index compared with nonusers.
* The augmentation index was similar between combustible cigarette smokers compared with sole e-cigarette users and dual users.
* Endothelial cells from combustible cigarette smokers and sole e-cigarette users produced less nitric oxide in response to a23187 stimulation compared with nonsmokers.
* The study suggests that e-cigarette use is not associated with a more favorable vascular profile.
* Further longitudinal studies are needed to evaluate the long-term risks of sustained e-cigarette use.

Main Message:
The main message of the text is that e-cigarette use is not associated with a more favorable vascular profile compared with combustible cigarette smoking. The study's findings suggest that e-cigarette use may not be a safer alternative to combustible cigarettes. The study also highlights the need for further research to evaluate the long-term risks of sustained e-cigarette use. The study's findings have important implications for the regulation and use of e-cigarettes as a harm reduction tool for combustible cigarette smokers.

Fetterman JL, Keith RJ, Palmisano JN, et al. alterations in Vascular Function associated With the Use of Combustible and Electronic Cigarettes. Journal of the american heart association. 2020;9(9):1. doi:10.1161/Jaha.119.014570