Exposure to Nicotine Vapor Produced by an Electronic Nicotine Delivery System Causes Short-Term Increases in Impulsive Choice in adult Male Rats.

Introduction:
In this study, the authors investigate the effects of nicotine vapor exposure on impulsive choice in rats. The study uses a rodent nicotine vapor delivery system to expose rats to different concentrations of nicotine vapor and measures their impulsive choice using a delay discounting task. The study aims to determine the short- and long-term effects of nicotine vapor exposure on impulsive choice.

Key points:

* The study used a rodent nicotine vapor delivery system to expose rats to different concentrations of nicotine vapor.
* The study measured impulsive choice using a delay discounting task.
* The study found that rats exposed to nicotine vapor displayed higher serum cotinine levels than control rats.
* There were no differences in impulsive choice between any vapor exposure groups when tested 15 days after exposure.
* a subsequent nicotine vapor challenge revealed short-term increases in impulsive choice immediately following a single exposure to 24 mg/mL nicotine vapor.
* The study suggests that exposure to nicotine vapor causes immediate, short-term increases in impulsive choice.
* The study highlights the need for further research into the effects of nicotine vapor exposure on the brain and behavior.

Main message:
The study provides valuable insights into the effects of nicotine vapor exposure on impulsive choice in rats. The findings suggest that exposure to nicotine vapor produces short-term increases in impulsive choice, which is a concern given the increasing popularity of e-cigarettes among adolescents and young adults. The study highlights the need for further research into the psycho-pharmacological, neurobiological, and behavioral effects of nicotine vapor consumption. The use of a rodent nicotine vapor delivery system in this study provides a viable model for future research in this area. Overall, the study underscores the importance of regulating nicotine vapor products and protecting public health.

Flores RJ, alshbool FZ, Giner P, O’Dell LE, Mendez Ia. Exposure to Nicotine Vapor Produced by an Electronic Nicotine Delivery System Causes Short-Term Increases in Impulsive Choice in adult Male Rats. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 2022;24(3):358-365. doi:10.1093/ntr/ntab141