Potential factors affecting free base nicotine yield in electronic cigarette aerosols.

Introduction:
This text summarizes a study investigating the factors that affect the yield of free base nicotine in electronic cigarette (e-cigarette) aerosols. The study identifies several factors that influence the free base nicotine yield, including flavor, battery power output, nicotine compound type, and propylene glycol (PG) to vegetable glycerin (VG) ratios. additionally, the study examines the degradation of nicotine salicylate and its impact on free base nicotine yield.

Key Points:

* The study used a validated aerosol generating model to generate e-cigarette aerosols.
* The aerosols were collected on Cambridge filters and analyzed for free base nicotine yield.
* The study found that flavors, battery power output, nicotine compound type, and PG:VG ratios affect free base nicotine yield.
* The degradation of nicotine salicylate was found to be a significant factor affecting free base nicotine yield in e-cigarette aerosols.
* The study used a syringe pump-based vaping machine, Sensirion air sensor, DOVPO Trigger 168 W TC Box mod electronic cigarette, Cambridge filters, and mass spectrometry for analysis.
* The study used pure nicotine, nicotine salicylate, and nicotine benzoate as nicotine compounds.
* Three different flavors (mango, menthol, and tobacco) and two vaping profiles (90 W and 120 W) were used in the study.
* The study used unflavored e-liquids with different PG:VG ratios (100:0, 70:30, 30:70, and 0:100 v/v) to examine the effect of PG:VG ratios on free base nicotine yield.

Main Message:
The study highlights the importance of understanding the factors that affect the yield of free base nicotine in e-cigarette aerosols. The findings of this study can help inform better regulations of e-cigarettes and address the nicotine addiction concern among the population. The study suggests that limiting the nicotine concentration in e-cigarette products, regulating e-cigarette devices, and implementing stricter regulations on e-liquid flavors can help reduce the negative health impacts associated with e-cigarette use. additionally, the study emphasizes the need for further research on the degradation of nicotine salicylate and its impact on free base nicotine yield in e-cigarette aerosols. Overall, the study underscores the importance of a comprehensive approach to regulating e-cigarettes, including regulations on devices, e-liquids, and nicotine concentration.

Gholap VV, Pearcy aC, halquist MS. Potential factors affecting free base nicotine yield in electronic cigarette aerosols. Expert opinion on drug delivery. 2021;18(7):979-989. doi:10.1080/17425247.2021.1890714