Determining the impact of flavored e-liquids on aldehyde production during Vaping.

Introduction:
This article presents a study on the impact of flavored e-liquids on the production of aldehydes during vaping. The researchers used 10 ENDS devices to test five e-liquid formulations, including four flavored and one non-flavored, and measured device mass loss and levels of acetaldehyde, acrolein, and formaldehyde. The study aimed to determine the variability in measurements and the impact of flavor compounds on aldehyde production.

Key Points:

* The study found reasonable variability in measurements of device mass loss, but two outlier devices produced high levels of aldehydes.
* after removing the outlier devices, acceptable variability in aerosol levels of acetaldehyde and formaldehyde was found.
* The flavored formulations tested resulted in a consistent and selective increase of 150% - 200% in acetaldehyde levels, no change or decrease in acrolein, and varying effects on formaldehyde levels.
* Comparison with previous literature showed the need for a standardized ENDS testing protocol.
* Device variability must be fully characterized and considered before assessing the impact of e-liquid formulations.

Main Message:
The study highlights the importance of accounting for device variability in assessing the impact of e-liquid formulations on aldehyde production. The researchers emphasize the need for a standardized testing protocol to ensure accurate and reliable results. The findings support the need for further research in this area to ensure the safe use of ENDS products.

Gillman IG, Pennington aSC, humphries KE, Oldham MJ. Determining the impact of flavored e-liquids on aldehyde production during Vaping. Regulatory toxicology and pharmacology : RTP. 2020;112:104588. doi:10.1016/j.yrtph.2020.104588