Electronic cigarette vaping with aged coils causes acute lung injury in mice.

Introduction:
This text provides an analysis of the relationship between coil age and acute lung injury in mice exposed to experimental vaping. The study investigates the concentrations of formaldehyde and acetaldehyde in the vaping aerosols and their impact on lung function.

Key points:

* The concentrations of formaldehyde and acetaldehyde in the vaping aerosols increased with age of the nichrome coils starting at 1200 puffs.
* Mice exposed to e-cigarette aerosols produced from 1800, but not 0 or 900, puff-aged coils caused acute lung injury, increased lung wet/dry weight ratio, and induced lung inflammation (IL-6, TNF-α, IL-1β, MIP-2).
* Exposure to vaping aerosols from 1800 puff-aged coils decreased heart rate, respiratory rate, and oxygen saturation in mice compared to mice exposed to air or aerosols from new coils.
* The study shows that the concentration of aldehydes (formaldehyde and acetaldehyde) increased with repeated and prolonged usage of e-cigarette coils.
* Exposure to high levels of aldehyde in vaping aerosol was associated with acute lung injury in mice.
* The findings highlight the significant risk of lung injury associated with prolonged use of e-cigarette devices.

Main message:
The study underscores the potential health risks associated with the prolonged use of e-cigarette devices. The increased concentrations of aldehydes in vaping aerosols generated from aged coils can cause acute lung injury, lung inflammation, and adverse physiological effects in mice. These findings highlight the need for further research and regulation to ensure the safety of e-cigarette users.

Goto S, Grange RMh, Pinciroli R, et al. Electronic cigarette vaping with aged coils causes acute lung injury in mice. archives of toxicology. 2022;96(12):3363-3371. doi:10.1007/s00204-022-03388-x