Summary
Introduction:
This text provides an analysis of the study examining the relationship between electronic cigarette (e-cigarette) use and cardiovascular disease (CVD) risk factors. The study compares the effects of e-cigarettes and tobacco cigarettes (TC) on various biomarkers associated with CVD risk.
Key Points:
* The study enrolled 106 participants, including 32 e-cigarette users, 29 TC smokers, and 45 non-users.
* The study measured various biomarkers associated with CVD risk, including oxidized metabolites of polyunsaturated fatty acids, antioxidant capacity, and vascular injury and inflammation markers.
* The results showed that e-cigarette users had lower levels of oxidized metabolites of linoleic acid and arachidonic acid compared to non-users.
* Both e-cigarette users and TC smokers had higher levels of antioxidant defense markers compared to non-users.
* TC smokers had higher concentrations of heme oxygenase-1 and cluster of differentiation 14, markers of vascular injury and inflammation, respectively.
* The study also found that e-cigarette users had biomarker levels that were overall intermediate between non-users and TC smokers.
* The study's multivariable analysis demonstrated that e-cigarette users exhibited biomarker levels that were overall intermediate between non-users and TC smokers with a potential to be related to future adverse cardiovascular health effects.
Main Message:
The study suggests that e-cigarette use is associated with alterations in lipid metabolism, oxidative and inflammatory responses, and antioxidant defense mechanisms that are relevant to CVD risk. While e-cigarette users had lower levels of oxidized metabolites of linoleic acid and arachidonic acid compared to non-users, they also had higher levels of antioxidant defense markers and intermediate levels of vascular injury and inflammation markers. These findings suggest that e-cigarette use may have cardiovascular health effects that are similar to but less severe than TC smoking. Further research is needed to confirm these findings and to understand the long-term health effects of e-cigarette use.
Citation
Gupta R, Lin Y, Luna K, et al. Electronic and Tobacco Cigarettes alter Polyunsaturated Fatty acids and Oxidative Biomarkers. Circulation research. 2021;129(5):514-526. doi:10.1161/CIRCRESaha.120.317828
