Nicotine delivery and users’ reactions to Juul compared with cigarettes and other e-cigarette products.

Introduction:
This text summarizes a study that compares the pharmacokinetic (PK) profile and user reactions of Juul, a popular electronic cigarette (EC), with cigarettes and other EC products. The study aims to assess the therapeutic and dependence potential of Juul by comparing its nicotine delivery and user ratings with other products.

Key Points:

* The study used a cross-over, within-subjects design with 20 dual users (smokers who also vape) who attended after overnight abstinence on separate sessions and smoked a cigarette or used Juul or eight other types of EC products ad libitum for 5 minutes.
* The Juul product used was the version available in the United States, which has more nicotine in the e-liquid than the one available in the European Union.
* The number of puffs taken, blood samples, urges to smoke, and product ratings were measured at each session.
* The study found that Juul's PK profile was close to the PK profile of cigarettes, with a similar maximum concentration (Cmax) and time to maximum concentration (Tmax).
* Compared with other EC products, Juul had shorter Tmax and higher Cmax, despite a lower number of puffs.
* Juul also provided faster reduction of urges to smoke and obtained more favorable subjective ratings than other EC products.
* The study concludes that Juul's PK profile and user ratings suggest that it could be more effective than other EC products in helping smokers quit smoking, but it may also have a higher potential to generate regular use in non-smokers.

Main Message:
The study suggests that Juul's nicotine delivery and user ratings make it a potentially more effective tool for smoking cessation than other EC products. however, its PK profile and user ratings also indicate a higher potential for generating regular use in non-smokers. Therefore, it is crucial to regulate Juul's access and marketing to minimize the risks of nicotine dependence and use in non-smokers.

hajek P, Pittaccio K, Pesola F, Myers Smith K, Phillips-Waller a, Przulj D. Nicotine delivery and users’ reactions to Juul compared with cigarettes and other e-cigarette products. addiction (abingdon, England). 2020;115(6):1141-1148. doi:10.1111/add.14936