Electronic Cigarettes and Fecundability: Results From a Prospective Preconception Cohort Study.

Introduction:
This text discusses a study on the relationship between e-cigarette use and fecundability, or the average per-cycle probability of conception, in a cohort of North american women. The study also examines how this association varies according to combustible cigarette smoking behaviors.

Key Points:

* The study is a prospective cohort study of female pregnancy planners in the United States and Canada.
* E-cigarette use was measured at baseline and follow-up, and combustible cigarette smoking status and history were also assessed.
* Fecundability ratios and 95% confidence intervals were calculated using proportional probabilities models, controlling for potential confounders.
* Current e-cigarette use was associated with slightly reduced fecundability compared with never use, but estimates of its independent and joint associations with combustible cigarette smoking were inconsistent and imprecise.
* Dual use of e-cigarettes and combustible cigarettes might influence health differently from use of e-cigarettes alone.
* The study found that women who currently use e-cigarettes have a slightly reduced chance of becoming pregnant each cycle compared to those who have never used e-cigarettes.
* The association between e-cigarette use and fecundability varied according to combustible cigarette smoking behaviors.
* The study's results suggest that e-cigarette use may have a small impact on fertility, but more research is needed to confirm these findings.

Main Message:
The main message of this text is that e-cigarette use is associated with slightly reduced fecundability, but the association varies according to combustible cigarette smoking behaviors. The study's results suggest that e-cigarette use may have a small impact on fertility, but more research is needed to confirm these findings. It is important for women who are planning to become pregnant to be aware of this potential effect and to consider all the available evidence when making decisions about e-cigarette use. additionally, it is important for regulatory agencies to consider this potential effect when evaluating the safety of e-cigarettes.

harlow aF, hatch EE, Wesselink aK, Rothman KJ, Wise La. Electronic Cigarettes and Fecundability: Results From a Prospective Preconception Cohort Study. american journal of epidemiology. 2021;190(3):353-361. doi:10.1093/aje/kwaa067