Puff-Resolved analysis and Selected quantification of Chemicals in the Gas Phase of E-Cigarettes, heat-Not-Burn Devices, and Conventional Cigarettes Using Single-Photon Ionization Time-of-Flight Mass Spectrometry (SPI-TOFMS): a Comparative Study.

Introduction:
This text provides a summary of a scientific study comparing the chemical emissions of alternative nicotine delivery devices (aNDD) to conventional cigarettes. The study uses Single-photon ionization time-of-flight mass spectrometry (SPI-TOFMS) to analyze the gas-phase emissions of three aNDD and one conventional cigarette. The aNDD tested include an electrically heated tobacco product, a combustion heated tobacco product, and a first-generation electronic cigarette.

Key Points:

* The study used SPI-TOFMS to analyze the gas-phase emissions of three aNDD and one conventional cigarette.
* The aNDD tested include an electrically heated tobacco product, a combustion heated tobacco product, and a first-generation electronic cigarette.
* The puff-by-puff profile of all products was recorded.
* The aNDD show a substantial reduction or complete absence of known harmful and potentially harmful substances compared to the CC.
* Tar substances are formed to a much lower extent in aNDD.
* Nicotine, however, is supplied in comparable amounts except for the investigated electronic cigarette.
* The comparison of puff-resolved profiles of emissions from different tobacco products may help users switch to lower emission products.
* Puff-resolved comparison overcomes technical changes, use modes between products and may help in their regulation.

Main Message:
The study found that aNDD emit lower concentrations of harmful and potentially harmful substances compared to conventional cigarettes. The puff-resolved comparison of emissions from different tobacco products may help users switch to lower emission products and aid in their regulation. The study suggests that switching from conventional cigarettes to aNDD may reduce users' exposure to harmful substances, but further toxicological and epidemiological studies are needed to determine the health benefits.

heide J, adam TW, Jacobs E, et al. Puff-Resolved analysis and Selected quantification of Chemicals in the Gas Phase of E-Cigarettes, heat-Not-Burn Devices, and Conventional Cigarettes Using Single-Photon Ionization Time-of-Flight Mass Spectrometry (SPI-TOFMS): a Comparative Study. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 2021;23(12):2135-2144. doi:10.1093/ntr/ntab091