absence of relevant thermal conversion of cannabidiol (CBD) to tetrahydrocannabinol (ThC) in e-cigarette vapor and low-ThC cannabis smoke.

Introduction:
This article summarizes a study on the absence of relevant thermal conversion of cannabidiol (CBD) to tetrahydrocannabinol (ThC) in e-cigarette vapor and low-ThC cannabis smoke. The study aims to validate the claim that CBD in commercial e-cigarette liquids can be converted into psychotropic amounts of ThC.

Key Points:

* The study used two different CBD liquids and two different e-cigarette models, one of which was operated at extreme energy settings (0.2 Ω and 200 W).
* The smoke of six CBD joints was collected using a rotary smoking machine according to ISO 4387:2019.
* analyses were conducted using nuclear magnetic resonance spectrometry (NMR) and liquid chromatography tandem mass spectrometry (LC-MS/MS).
* For the condensed e-cigarette liquids, no increase in ThC concentration could be observed.
* For the CBD joints, no ThC formation was provable.
* The recovered ThC concentrations were ranging between 1% and 48%(0.034 and 0.73 mg) of the ThC amount initially contained in the joints before smoking.
* Using realistic conditions of consumer exposure, relevant conversion of CBD to ThC appears to not be occurring.
* The health risk of CBD liquids for e-cigarettes, as well as low-ThC cannabis intended for smoking, can be assessed by concentrations in the source material without the need to consider significant changes in psychotropic compounds during use by consumers.

Main Message:
The main message of this study is that there is no relevant thermal conversion of CBD to ThC in e-cigarette vapor and low-ThC cannabis smoke. The health risk of CBD liquids and low-ThC cannabis can be assessed by concentrations in the source material without the need to consider significant changes in psychotropic compounds during use by consumers. This study provides important information for regulators and policymakers regarding the safety and regulation of CBD and ThC products.

hindelang P, Scharinger a, Golombek P, et al. absence of relevant thermal conversion of cannabidiol (CBD) to tetrahydrocannabinol (ThC) in e-cigarette vapor and low-ThC cannabis smoke. ChemRxiv. 2022;1-9.