Systematic review on e-cigarette and its effects on weight gain and adipocytes.

Smoking and obesity are leading causes of morbidity and mortality worldwide. E-cigarette
which was first introduced in 2000s is perceived as an effective alternative to conventional
tobacco smoking. Limited knowledge is available regarding the risks and benefits of e-cigarettes.
This study systematically reviews the current literature on the effects of e-cigarettes
on body weight changes and adipocytes. The search was performed using OVID Medline
and Scopus databases and studies meeting the inclusion criteria were independently
assessed. This review included all English language, empirical quantitative and qualitative
papers that investigated the effects of e-cigarettes on bodyweight or lipid accumulation or
adipocytes. Literature searches identified 4965 references. After removing duplicates and
screening for eligibility, thirteen references which involve human, in vivo and in vitro studies
were reviewed and appraised. High prevalence of e-cigarette was reported in majority of the
cross sectional studies conducted among respondent who are obese or overweight. More
conclusive findings were identified in in vivo studies with e-cigarette causing weight
decrease. However, these observations were not supported by in vitro data. Hence, the
effect of e-cigarette on body weight changes warrants further investigations. Well-designed
population and molecular studies are needed to further elucidate the role of e-cigarettes in
obesity.

hod R, Mohd Nor Nh, Maniam S. Systematic review on e-cigarette and its effects on weight gain and adipocytes. PloS one. 2022;17(7):1. doi:10.1371/journal.pone.0270818