Repeated nicotine vapor inhalation induces behavioral sensitization in male and female C57BL/6 mice.

Introduction:
This text is a systematic review of the effects of e-cigarette use on lung function. It discusses the findings of eight studies that examined the immediate and long-term effects of e-cigarette use on measures of lung function.

Key Points:

* The review identified eight studies that met the inclusion criteria, with seven studies examining immediate effects and one study examining long-term effects.
* The studies included a total of 273 participants.
* The risk of bias was assessed using the Risk of Bias in Non-randomized Studies —of Interventions (ROBINS-I) and Cochrane risk of bias tools.
* The studies suggest that vaping increases airway resistance but does not appear to impact FEV1, FVC, or FEV1/FVC ratio.
* however, the limited size and follow-up duration of these studies make it difficult to determine the long-term effects of e-cigarettes on lung function.
* The authors call for larger, long-term studies to further determine the effects of e-cigarettes on lung function.

Main Message:
The main message of this text is that while some studies suggest that e-cigarette use may increase airway resistance, the overall evidence is limited and more research is needed to determine the long-term effects of e-cigarettes on lung function. The authors emphasize the need for larger, long-term studies to provide more definitive answers on the safety of e-cigarettes. In the meantime, they caution that e-cigarettes should not be considered risk-free and that users should be aware of the potential risks to their lung health.

honeycutt SC, Garrett PI, Barraza aG, Maloy aN, hillhouse TM. Repeated nicotine vapor inhalation induces behavioral sensitization in male and female C57BL/6 mice. Behavioural pharmacology. 2020;31(6):583-590. doi:10.1097/FBP.0000000000000562