Exposure, Retention, Exhalation, Symptoms, and Environmental accumulation of Chemicals During JUUL Vaping.

Introduction:
This text provides a comprehensive overview of exposure, retention, and ECEaR deposition for JUUL "Menthol" users. It details the transfer efficiency of nicotine, menthol, PG, and G, and the actual exposures and retention of these chemicals. The study also examines the symptoms reported by users during vaping and the potential doses of nicotine, PG, and G that JUUL users receive.

Key Points:

* The study found that nicotine, menthol, PG, and G were transferred with variable efficiency to EC aerosols and well retained by participants.
* The total mass retained (dose) in a 20 min vaping session ranged from 10.8 to 195.4 mg for the dominant chemicals.
* Retention of PG and G was close to 100% in most participants, and as a consequence, relatively low levels of chemicals appeared in ECEaR.
* Most users reported adverse symptoms, such as nausea, dizziness, and lightheadedness, during the 20 min vaping session.
* There was a significant correlation between the dose a participant received and the number of symptoms reported.
* The potential doses of nicotine, PG, and G that JUUL users receive are concerning, especially the solvents which are understudied.
* The potential for higher delivery and higher deposition of ECEaR may exist in other products, such as EC tanks/mods.
* The study highlights the need for further research into the long-term health effects of both JUUL use and passive exposure of nonusers to ECEaR.

Main Message:
The study emphasizes the importance of understanding the potential doses of nicotine, PG, and G that JUUL users receive, as well as the potential for higher delivery and higher deposition of ECEaR in other products. The significant correlation between the dose a participant received and the number of symptoms reported suggests that the adverse effects reported by users were caused by a combination of chemicals rather than an individual chemical. The study highlights the need for further research into the long-term health effects of both JUUL use and passive exposure of nonusers to ECEaR.

hua M, Luo W, Khachatoorian C, et al. Exposure, Retention, Exhalation, Symptoms, and Environmental accumulation of Chemicals During JUUL Vaping. Chemical research in toxicology. 2023;36(3):492-507. doi:10.1021/acs.chemrestox.2c00390