a systems toxicology approach for comparative assessment: Biological impact of an aerosol from a candidate modified-risk tobacco product and cigarette smoke on human organotypic bronchial epithelial cultures

This document is a summary of a research study related to microRNa (miRNa) expression in relation to exposure to a particular substance. The study was funded and sponsored by Philip Morris International R&D and all authors are employees of Philip Morris International R&D or were contracted by them. The researchers used Wilcoxon tests to detect miRNa probesets and only included those detected in more than 50% of the samples in at least one sample group for further analysis. a linear model for differential expression was applied to the resulting submatrices using the moderated t-statistic implemented in the limma package. The models included an additional variable to take into account exposure runs and adjusted p-values were obtained following multiple testing corrections using the Benjamini-hochberg FDR. The study's transparency document can be found in the online version of the article.

It is important to note that the specific context and details of the study are not fully provided in the text you've given, so a more detailed summary would not be possible without additional information. also, as I am an aI language model, I don't have the ability to access external information or databases, so I can't provide more context about the study itself, such as what the specific substance was that the samples were exposed to, or what the specific findings of the study were.

Iskandar, anita R., Carole Mathis, Walter K. Schlage, Stefan Frentzel, Patrice Leroy, Yang Xiang, alain Sewer, et al. “a Systems Toxicology approach for Comparative assessment: Biological Impact of an aerosol from a Candidate Modified-Risk Tobacco Product and Cigarette Smoke on human Organotypic Bronchial Epithelial Cultures.” Toxicology in Vitro 39 (March 2017): 29–51. https://doi.org/10.1016/j.tiv.2016.11.009.