Flavor Preference and Systemic Immunoglobulin Responses in E-Cigarette Users and Waterpipe and Tobacco Smokers: a Pilot Study.

Introduction:
This article reports the results of a pilot study examining the relationship between e-cigarette and other tobacco product usage, clinical respiratory symptoms, and immunoglobulin response in human subjects. The study collected self-reported data on tobacco product flavor preferences and plasma samples to test for immunoglobulin G (IgG) and E (IgE) levels.

Key Points:

* The study's cohort had a 47.9% flavor preference towards fruit flavors and a 63.1% preference to more sweet flavors.
* E-cigarette and traditional cigarette smokers were the two subject groups to report the most clinical symptoms.
* E-cigarette users had a significant increase in plasma IgE levels compared to non-tobacco users.
* Dual users had a significant increase in plasma IgG compared to non-tobacco users, cigarette smokers, and waterpipe smokers.
* The study suggests that users have a preference toward fruit and more sweet flavors and that e-cigarette and dual use resulted in an augmented systemic immune response.

Main Message:
The main message of this study is that e-cigarette and dual use resulted in an augmented systemic immune response, as indicated by a significant increase in plasma IgG and IgE levels. The study also highlights the importance of considering tobacco product flavor preferences in understanding usage patterns and potential health effects. Further research is needed to confirm these findings and to explore the long-term immune response based on flavors and clinical symptoms.

Jackson M, Singh KP, Lamb T, McIntosh S, Rahman I. Flavor Preference and Systemic Immunoglobulin Responses in E-Cigarette Users and Waterpipe and Tobacco Smokers: a Pilot Study. International journal of environmental research and public health. 2020;17(2). doi:10.3390/ijerph17020640