Vapor inhalation of cannabidiol (CBD) in rats.

Introduction:
This text provides a summary of a scientific study examining the effects of vaporized cannabidiol (CBD) inhalation in rats. The study aimed to validate an inhalation model to assess CBD effects and compare plasma CBD levels after vapor inhalation with those observed after injection. additionally, the study investigated hypothermia and anti-nociception produced by CBD inhalation.

Key Points:

* The study used an e-cigarette device to generate CBD vapor and expose rats for 30 minutes.
* Plasma CBD levels were measured after vapor inhalation and compared with levels obtained after injection.
* CBD inhalation produced dose-related hypothermia in male Sprague-Dawley rats, while i.p. injection did not.
* CBD inhalation had no effect on anti-nociception alone or in combination with Δ9-tetrahydrocannabinol inhalation.
* The vapor-inhalation approach is a suitable pre-clinical model for investigating the effects of inhaled CBD.
* The study found that CBD inhalation produces hypothermia in rats, while i.p. injection does not, at comparable plasma CBD levels.
* The study also highlights the importance of considering the route of administration when studying the effects of CBD.

Main Message:
The study highlights the potential risks and benefits of CBD inhalation, particularly in relation to hypothermia. The findings suggest that the route of administration is crucial in determining the effects of CBD, which has important implications for the development of CBD products and their regulation. The study underscores the need for further research to fully understand the risks and benefits of CBD inhalation and to inform regulatory decisions.

Javadi-Paydar M, Creehan KM, Kerr TM, Taffe Ma. Vapor inhalation of cannabidiol (CBD) in rats. Pharmacology, biochemistry, and behavior. 2019;184:172741. doi:10.1016/j.pbb.2019.172741