Toxicological assessment of Particulate and Metal hazards associated with Vaping Frequency and Device age.

Introduction:
This article reports on a study examining the impact of vaping frequency and device age on the toxicological properties of electronic nicotine delivery system (ENDS) aerosols. The study utilized an automated multi-channel ENDS aerosol generation system to generate aerosols from JUUL pod-type ENDS using tobacco-flavored e-liquid. aerosol puff fractions (1-50) and (101-150) were monitored and sampled using various collection media. Extracted aerosols were prepared for metal and toxicological analysis using human primary small airway epithelial cells (SaEC).

Key Points:

* The study found that later puff fraction aerosols contained higher toxic metal concentrations, including chromium, copper, and lead.
* These metals elicited increased levels of ROS, followed by significant declines in total glutathione and cell viability.
* a 30% increase in DNa damage was observed after 7 days of exposure to later puff fraction aerosols.
* The findings suggest that ENDS aerosols may become more hazardous across the use of pre-filled pod devices, which may threaten respiratory health.
* The study highlights the need for further investigation into the potential health risks associated with ENDS usage, particularly in relation to device aging and vaping behavior.

Main Message:
This study provides important insights into the potential health risks associated with ENDS usage, particularly in relation to device aging and vaping frequency. The findings suggest that ENDS aerosols may become more hazardous across the use of pre-filled pod devices, which may threaten respiratory health. Given the growing popularity of ENDS devices, particularly among young people, it is essential that further research is conducted to better understand the potential health risks associated with their use. as a regulatory expert, it is crucial that we consider these findings when developing regulations and guidelines around ENDS usage to ensure the protection of public health.

Jeon J, Zhang q, Chepaitis PS, Greenwald R, Black M, Wright C. Toxicological assessment of Particulate and Metal hazards associated with Vaping Frequency and Device age. Toxics. 2023;11(2). doi:10.3390/toxics11020155