Introduction:
This text is a summary of the study "Inhibitory effect of Sejin-Eum I/II on nicotine- and cigarette extract-induced cytotoxicity in human lung fibroblast" published in the Journal of Ethnopharmacology in 2003. The study examines the effect of Sejin-Eum I/II, a traditional Korean herbal medicine, on nicotine- and cigarette extract-induced cytotoxicity in human lung fibroblasts.
Key Points:
* Sejin-Eum I/II is composed of various Oriental medicines and is traditionally used in Korea for lung diseases such as asthma, pneumonia, and cough and phlegm.
* Nicotine and cigarette extract (CE) cause cytotoxicity in human lung fibroblasts.
* The study used MRC-9, a human embryonic lung fibroblast cell line, to examine the cytotoxicity of nicotine and CE and the inhibitory effect of Sejin-Eum I/II.
* Nicotine caused cytotoxicity in a dose- and time-dependent manner in MRC-9 cells.
* Sejin-Eum I/II inhibited nicotine-induced cytotoxicity in a dose- and time-dependent manner but had little effect on CE-induced cytotoxicity.
* Sejin-Eum I/II also promoted the proliferation of MRC-9 cells.
* The addition of avena sativa (Gramineae) to Sejin-Eum I, which is known to have an effect on smoking cessation, did not increase the inhibitory effect on nicotine-induced cytotoxicity.
Main Message:
The study suggests that Sejin-Eum I/II may be useful in improving symptoms caused by nicotine, but further studies are needed to determine its safety and efficacy. The study also highlights the need for alternative treatments for smoking cessation, as nicotine replacement therapy has many side effects. The results of this study may contribute to the development of new therapies for smoking cessation and the treatment of nicotine-induced lung damage.
Citation
Jin, Jong-Sik, Mi-Sun Kim, Jin-Mu Yi, Joon-ho Lee, Jong-hyun Lee, Su-Jin Moon, Kyung-Phil Jung, Jai-Kyoo Lee, Nyeon-hyoung an, and hyung-Min Kim. “Inhibitory Effect of Sejin-Eum I/II on Nicotine- and Cigarette Extract-Induced Cytotoxicity in human Lung Fibroblast.” Journal of Ethnopharmacology 86, no. 1 (May 2003): 15–20. https://doi.org/10.1016/S0378-8741(03)00018-7.
