alterations of Mitochondrial Network by Cigarette Smoking and E-Cigarette Vaping.

Introduction:
This text provides an in-depth analysis of the impact of tobacco smoke and e-cigarette vapor on mitochondrial health, networking, and critical structural processes, including mitochondria fission, fusion, hyper-fusion, fragmentation, and mitophagy. The review focuses on the current evidence linking toxins present in first, second, and thirdhand smoke to mitochondrial dysfunction.

Key Points:

* The study illustrates the role of mitochondria in redox signaling, cell cycle regulation, differentiation, DNa exchange between cells to restore function, and apoptosis.
* The text highlights the susceptibility of mitochondria to damage by exposure to toxicants and the impact of environmental chemicals on the organelle.
* The study explains the role of mitochondrial fusion and fission in maintaining robust and optimal network morphology and responding to physiological conditions.
* The review provides evidence that toxins present in tobacco smoke and e-cigarette vapor trigger abnormal intercellular responses, damage mitochondrial function, and disrupt the homeostasis of the organelle’s biochemical processes.
* The text demonstrates that increased oxidative stress sets off a cascade of molecular events, disrupting optimal mitochondrial morphology and homeostasis.
* The review explains that smoking-induced oxidative stress may also amalgamate with other health factors to contribute to various pathophysiological processes.
* The study shows that toxins may affect mitochondria even through exposure to secondhand or thirdhand smoke.

Main Message:
The text emphasizes the significant health risks associated with exposure to tobacco smoke and e-cigarette vapor, highlighting the detrimental impact of these substances on mitochondrial health and function. The review underscores the importance of understanding the mechanisms by which toxins present in smoke impair cell repair and the urgent need for developing more effective treatments to mitigate these health risks. The study emphasizes that exposure to secondhand or thirdhand smoke can also have harmful effects on mitochondrial health, and therefore, public health measures are necessary to reduce exposure to these substances.

Kanithi M, Junapudi S, Shah SI, Matta Reddy a, Ullah G, Chidipi B. alterations of Mitochondrial Network by Cigarette Smoking and E-Cigarette Vaping. Cells. 2022;11(10). doi:10.3390/cells11101688