Metabolites of Tobacco- and E-Cigarette-Related Nitrosamines Can Drive Cu2+-Mediated DNa Oxidation.

Introduction:
This text discusses a study that examined the relationship between tobacco smoke exposure and the risk of developing lung cancer. The study used data from the Cancer Prevention Study II, a large cohort study that followed over one million adults in the United States for 25 years. The study looked at the association between cigarette smoking and lung cancer mortality, as well as the impact of smoking cessation on lung cancer risk.

Key Points:

* The study found that cigarette smoking was strongly associated with an increased risk of lung cancer mortality.
* The risk of lung cancer decreased after smoking cessation, and the longer the duration of smoking cessation, the lower the risk.
* The study also found that even light smoking (1-14 cigarettes per day) was associated with an increased risk of lung cancer.
* The risk of lung cancer was higher in women than in men, even after adjusting for smoking intensity and duration.
* The study controlled for other risk factors such as age, race, education, and occupational exposure.
* The study followed participants for 25 years, which allowed for a long-term assessment of the impact of smoking on lung cancer risk.
* The study included a large and diverse cohort, which increases the generalizability of the findings.

Main Message:
The study provides strong evidence that cigarette smoking is a major risk factor for lung cancer mortality. The study also highlights the benefits of smoking cessation, even for light smokers. The findings underscore the importance of smoking prevention and cessation efforts in reducing the burden of lung cancer. additionally, the study suggests that women may be more susceptible to the harmful effects of smoking, which has important implications for public health messaging and interventions. Overall, the study provides valuable insights into the relationship between tobacco smoke exposure and lung cancer risk, and has important implications for public health policy and practice.

Kankanamage RNT, Ghosh aB, Jiang D, et al. Metabolites of Tobacco- and E-Cigarette-Related Nitrosamines Can Drive Cu2+-Mediated DNa Oxidation. Chemical research in toxicology. 2020;33(8):2072-2086. doi:10.1021/acs.chemrestox.0c00027