Elevated Cellular Oxidative Stress in Circulating Immune Cells in Otherwise healthy Young People Who Use Electronic Cigarettes in a Cross-Sectional Single-Center Study: Implications for Future Cardiovascular Risk.

Introduction:
This text provides an overview of a study examining the relationship between tobacco product use and cardiovascular disease. The study focuses on the impact of electronic cigarette (EC) vaping on immune cells and compares it to the effects of tobacco cigarette (TC) smoking. The study also considers the potential of ECs as a harm-reduction strategy for smokers.

Key Points:

* The study included 33 participants, divided into three groups: nonsmokers, EC vapers, and TC smokers.
* The study used flow cytometry and fluorescent probes to quantify the relative immune cell-type populations and their intracellular content of ROS in the three groups.
* The study found a dose-response relationship between tobacco product use and immune cell activation and oxidative stress.
* The effects of EC vaping were intermediate between nonsmokers and TC smokers, but still significant.
* Plasma cotinine levels were used to estimate the relative tobacco product burden in EC vapers and TC smokers.
* The study suggests that long-term EC vaping is associated with increased innate and adaptive immunity and oxidative stress.
* The study calls for further research to determine if switching to ECs may avoid activation of downstream detrimental cellular pathways, supporting their role as part of a harm-reduction strategy for cardiovascular disease.

Main Message:
The study provides important insights into the relationship between tobacco product use and cardiovascular disease. The findings suggest that while ECs may be less harmful than TCs, they are still associated with increased immune cell activation and oxidative stress. Further research is needed to determine the long-term health effects of EC use and their potential as a harm-reduction strategy for smokers. The study highlights the need for caution when promoting ECs as a safe alternative to smoking, as they are still associated with significant health risks.

Kelesidis T, Tran E, arastoo S, et al. Elevated Cellular Oxidative Stress in Circulating Immune Cells in Otherwise healthy Young People Who Use Electronic Cigarettes in a Cross-Sectional Single-Center Study: Implications for Future Cardiovascular Risk. Journal of the american heart association. 2020;9(18):1. doi:10.1161/Jaha.120.016983