Effects of Common e-Liquid Flavorants and added Nicotine on Toxicant Formation during Vaping analyzed by 1h NMR Spectroscopy.

Introduction:
This article reports the findings of a study that analyzed the impact of individual e-liquid components, specifically nicotine and common flavorants, on carbonyl production during vaping using 1h NMR spectroscopy. The study aimed to determine the effect of these components individually and together on the formation of harmful and potentially harmful constituents (hPhCs) in the aerosols produced by vaping.

Key Points:

* The study used e-liquids with and without flavorants and nicotine and vaped them using a specific device and puff protocol.
* The aerosolized samples were collected and analyzed using 1h NMR spectroscopy to determine the levels of various hPhCs.
* The study found that the addition of flavorants and nicotine to e-liquids can significantly increase the formation of certain hPhCs, including acetaldehyde, acrolein, and formaldehyde.
* however, the effect of nicotine on hPhC formation depends on the specific flavorants present in the e-liquid.
* The study also found that the percentage of aerosol collected can be affected by the addition of certain flavorants and nicotine to e-liquids.
* The levels of multiple addition products (MaPs) were also determined in the aerosolized samples, which can be formed by the addition of formaldehyde to glycerol and exhibits triplet peaks at 5.8, 5.3, and 5.1 ppm.
* The study used various methods to identify and quantify the degradation products formed during vaping, including the addition of specific substances to the e-liquids and analyzing the resulting peaks in the NMR spectra.

Main Message:
The study highlights the importance of understanding the impact of individual e-liquid components, specifically nicotine and flavorants, on hPhC formation during vaping. The findings suggest that the addition of certain flavorants and nicotine to e-liquids can significantly increase the formation of harmful constituents, which can have implications for the health of e-cigarette users. Therefore, it is crucial to regulate the use of these components in e-liquids to ensure the safety of e-cigarette users. as an expert in regulatory matters, it is essential to consider these findings when developing regulations for e-cigarettes and e-liquids.

Kerber PJ, Duell aK, Powers M, Strongin RM, Peyton Dh. Effects of Common e-Liquid Flavorants and added Nicotine on Toxicant Formation during Vaping analyzed by 1h NMR Spectroscopy. Chemical research in toxicology. 2022;35(7):1267-1276. doi:10.1021/acs.chemrestox.2c00110