Summary
This systematic review by Paulina Natalia Kopa-Stojak and Rafał Pawliczak from the Department of Immunopathology, Division of Biomedical Science, Faculty of Medicine, Medical University of Lodz, Lodz, Poland focuses on the effects of cigarettes, electronic nicotine delivery systems (ENDS), and tobacco heating products (ThP) on miRNa-mediated gene expression regulation and their possible impact on smoking-related respiratory disease development.
The review includes a study by Song et al. (2020) which compared the effects of e-cigarette use and never-smoking on never-smokers divided into two arms: e-cigarette and control. The e-cigarette group used nicotine- and flavor-free liquids for 5 weeks. The study found a higher level of propylene glycol (PG) in the e-cigarette vs. control group (p <0.0015). additionally, in the e-cigarette group, there was a statistically significant correlation in PG level and total cell concentration, macrophages count, and lymphocytes count. There was also a significant correlation in PG level and pro-inflammatory cytokines secretion: IL-8, IL-13, and TNF- a. however, there were no significant changes in mRNa/miRNa between groups.
In summary, the review provides evidence that e-cigarette use affects miRNa-mediated gene expression regulation, with an increase in propylene glycol levels correlating with changes in total cell concentration, macrophages count, lymphocytes count, and pro-inflammatory cytokines secretion. however, the study did not find significant changes in mRNa/miRNa between the e-cigarette and control groups. The review highlights the need for further research to fully understand the impact of e-cigarette use on smoking-related respiratory disease development.
Citation
Kopa-Stojak PN, Pawliczak R. Comparison of effects of tobacco cigarettes, electronic nicotine delivery systems and tobacco heating products on miRNa-mediated gene expression. a systematic review. Toxicology mechanisms and methods. 2023;33(1):18-37. doi:10.1080/15376516.2022.2089610
