acute effects of e-cigarette vaping on pulmonary function and airway inflammation in healthy individuals and in patients with asthma.

Introduction:
This text discusses the acute effects of e-cigarette vaping on pulmonary function and airway inflammation in healthy individuals and patients with asthma. The study compares the changes in pulmonary function and airway inflammation markers before and after vaping one e-cigarette between a group of asthmatic smokers and a matched sample of healthy smokers.

Key Points:

* The study included 25 asthmatic smokers and 25 healthy smokers matched for age, gender, BMI, and pack/years.
* Participants vaped an e-cigarette for 5 minutes and underwent pulmonary function tests, impulse oscillometry system measurements, exhaled nitric oxide measurements, and exhaled breath condensate collection before and after vaping.
* after e-cigarette vaping, FEV1/FVC and PEF decreased in asthmatic patients, while flow resistance increased in both groups.
* EBC ph increased in asthmatic patients and decreased in healthy controls, while FeNO increased in asthmatic patients and decreased in healthy controls.
* The concentrations of IL-10, TNF-α, and ISO8 increased in asthmatic patients after e-cigarette vaping.
* The changes in concentrations of IL-1β and IL-4 differed significantly between the two groups.

Main Message:
The study suggests that e-cigarette vaping results in acute alteration of both pulmonary function and airway inflammation in stable moderate asthmatic patients. This finding highlights the need for further studies on the long-term effects of e-cigarette use in individuals with respiratory conditions.

Kotoulas SC, Pataka a, Domvri K, et al. acute effects of e-cigarette vaping on pulmonary function and airway inflammation in healthy individuals and in patients with asthma. Respirology (Carlton, Vic). 2020;25(10):1037-1045. doi:10.1111/resp.13806