Summary
Introduction:
This text is a scientific article that investigates the pro-inflammatory effects of aerosols from e-cigarette-derived flavoring chemicals on murine macrophages. The study hypothesized that aerosol exposure to flavoring chemicals found in commercially available flavored e-liquids would result in an increase in pro-inflammatory cytokines in macrophages.
Key Points:
* The study used Raw264.7 macrophage cell lines and exposed them to a low and high dose of propylene glycol/vegetable glycerin (PG/VG) with almond flavoring benzaldehyde, PG/VG with spicy/clove flavoring eugenol, or PG/VG with apple flavoring hexyl acetate.
* Exposure to PG/VG with 2.1 mg/ml benzaldehyde resulted in a significant increase in KC levels compared to air and PG/VG exposed cells.
* Exposure to PG/VG with both doses of hexyl acetate resulted in a significant increase in KC and IL-6 levels compared to air exposed cells.
* Exposure to PG/VG with both doses of eugenol resulted in a significant increase in KC and IL-6 levels compared to air and PG/VG exposed cells.
* The study indicates the ability of aerosol exposure to e-cigarette flavoring chemicals to significantly increase pro-inflammatory cytokine release in macrophages.
Main Message:
The study provides evidence that aerosol exposure to flavoring chemicals found in e-cigarettes can induce an inflammatory response in macrophages, which could potentially lead to adverse health effects. The findings suggest the need for further studies to determine toxicological profiling for flavoring chemicals found in e-cigarettes and potential regulations of e-cigarette products containing flavoring chemicals.
Citation
Lamb T, Rahman I. Pro-inflammatory effects of aerosols from e-cigarette-derived flavoring chemicals on murine macrophages. Toxicology reports. 2023;10:431-435. doi:10.1016/j.toxrep.2023.04.003
